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Related Experiment Video

Updated: Jul 16, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

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Published on: April 23, 2021

Multi-element Exposure and Cognitive Function in Rural Elderly Chinese.

Lidan Duan^1,2, Liqin Su³, Xiaohong He⁴

¹China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.

Biological Trace Element Research

|September 16, 2023

Summary

Higher selenium and copper levels are linked to better cognitive function in rural elderly. Selenium also mitigates calcium

Keywords:

Cognitive function Combined exposure Heavy metal Older adults Selenium Trace elements

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Area of Science:

Environmental Health
Nutritional Epidemiology
Gerontology

Background:

Cognitive decline is a significant concern in aging populations.
Environmental factors, including trace element exposure, may influence cognitive health.
Understanding the complex interplay of multiple elements is crucial for targeted interventions.

Purpose of the Study:

To examine the association between multi-element exposure, particularly selenium (Se), and cognitive function in rural elderly individuals.
To identify specific elements correlated with cognitive performance.
To investigate potential interactions between elements affecting cognition.

Main Methods:

Cross-sectional study of 416 elderly individuals (≥60 years) in Enshi county, China.
Measurement of whole blood element concentrations (Se, Cu, Fe, Zn, Ca, Mg, Cd, As, Pb) using Inductively Coupled Plasma Mass Spectrometry (ICP-MS).
Assessment of cognitive function via nine standard tests and statistical analysis using LASSO, ANCOVA, and GLM.

Main Results:

Selenium (Se), Copper (Cu), Iron (Fe), Zinc (Zn), Calcium (Ca), and Lead (Pb) were independently associated with cognition.
Higher Se and Cu levels correlated with better cognitive function.
Higher Ca levels were associated with poorer cognitive function, but Se mitigated this negative effect.

Conclusions:

Elevated selenium and copper levels are beneficial for cognitive function in the elderly.
Selenium plays a protective role, counteracting the detrimental effects of calcium on cognition.
These findings highlight the importance of trace element status for maintaining cognitive health in aging rural populations.