Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

305
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
305
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

3.0K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Depressive symptoms in youth with refractory epilepsy: Exploration of seizure, sociodemographic and cognitive factors.

Epilepsy & behavior : E&B·2025
Same author

HIV and new onset seizures: slipping through the cracks in HIV care and treatment.

HIV medicine·2015
Same author

Carbamazepine and phenytoin: combination versus single drug therapy.

European journal of neurology·2013
Same author

Isolated seizures in rats do not cause neuronal injury.

Acta neurologica Scandinavica·2011
Same author

fMRI language dominance and FDG-PET hypometabolism.

Neurology·2011
Same author

Arterial spin labeling demonstrates that focal amygdalar glutamatergic agonist infusion leads to rapid diffuse cerebral activation.

Acta neurologica Scandinavica·2009

Related Experiment Video

Updated: Jul 16, 2025

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.8K

Cognitive function and the longitudinal hippocampal axis in mesial temporal sclerosis.

L Reppert1, L N Sepeta1, D Panjeti-Moore2

  • 1National Institute of Neurological Disorders and Stroke, United States; Department of Neurology, Children's National Medical Center, United States.

Epilepsy & Behavior : E&B
|September 16, 2023
PubMed
Summary

Preoperative memory deficits in mesial temporal lobe epilepsy (mTLE) with hippocampal sclerosis (HS) correlate with specific hippocampal regions. The left hippocampal tail is crucial for verbal memory, supporting functional differences along the hippocampal axis.

More Related Videos

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.1K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.6K

Related Experiment Videos

Last Updated: Jul 16, 2025

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice
07:03

Evaluation of Hemisphere Lateralization with Bilateral Local Field Potential Recording in Secondary Motor Cortex of Mice

Published on: July 31, 2019

6.8K
Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
12:09

Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy

Published on: August 5, 2014

18.1K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.6K

Area of Science:

  • Neuroscience
  • Epileptology
  • Cognitive Psychology

Background:

  • Mesial temporal lobe epilepsy (mTLE) with hippocampal sclerosis (HS) often presents with preoperative memory deficits.
  • The precise relationship between the distribution of neuronal loss in the hippocampus and specific memory impairments remains unclear.
  • Material specificity theory suggests distinct hippocampal subregions are involved in different memory types.

Purpose of the Study:

  • To investigate the association between preoperative memory deficits and the topographical distribution of neuronal loss within the hippocampus in patients with mTLE and HS.
  • To test the hypothesis that visual memory deficits relate to posterior hippocampal atrophy and verbal memory deficits to anterior hippocampal atrophy.

Main Methods:

  • Studied 22 adults with mTLE and HS, measuring hippocampal head, body, and tail volumes using automated segmentation.
  • Assessed preoperative memory using the Wechsler Memory Scale (WMS-II) subtests.
  • Correlated memory performance with hippocampal subfield volumes using statistical analyses, including linear regression.

Main Results:

  • Significant volumetric differences were found between hippocampal subdivisions (head, body, tail), with the head being largest.
  • Ipsilateral hippocampi were significantly smaller than contralateral hippocampi in both left and right mTLE groups.
  • Left hippocampal tail volume was the strongest predictor of logical memory performance; right hippocampal models showed a trend for predicting visual and verbal memory.

Conclusions:

  • The hippocampal head and tail appear more vulnerable to injury than the body in mTLE with HS.
  • Evidence suggests functional specialization along the hippocampal longitudinal axis, especially the left hippocampal tail for verbal memory.
  • Findings support material-specific lateralization of memory processing in the human brain.