Phase coherent quasi-particle formation in biological systems

The problem of the origin of canonical and aberrant DNA mutations and the contribution of protons to genetic stability is an essential topic in molecular biology. Based on the empirical results, we reconsidered canonical and tautomeric mutations under the two-fluid model of quantum physics. We assumed that the pressure exerted by protons (H⁺) in the DNA environment, through changes in pH, could alter the concentration ratio of canonical and tautomeric base pairs, which were found to be different at and beyond the criticality level, respectively. We anticipate that the deviation of the cellular system from a specific (critical) temperature at which dynamic entropy reaches a minimum and a critical pH occurs could result in tautomerization and point mutations.