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Updated: Jul 16, 2025
Author Spotlight: Expanding Interventional Pulmonology Research with Robotic-Assisted Bronchoscopy
Published on: July 19, 2024
Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy: series of 50 cases
E Salcedo Lobera1, F M Páez Codeso1, E Casado Miranda1
1Unidad de Gestión Clínica Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Regional Universitario de Málaga, Málaga, Spain.
Introduction:
Endobronchial ultrasonography-guided transbronchial fine-needle aspiration (EBUS-TBNA) has the drawback of providing small sample sizes for accurate diagnosis. Transbronchial mediastinal cryobiopsy (EBUS-TBCB), which allows for larger samples, could improve diagnostic yield.
Methods:
We prospectively studied 50 patients with mediastinal lymphadenopathy who underwent EBUS-TBNA and EBUS-TBCB in a single procedure.
Results:
EBUS-TBCB improved the diagnostic performance compared with EBUS-TBNA from a definite diagnosis of 32 (64%) patients to 45 (90%) patients [difference 26% (95% confidence interval: 14-40%, p<0.05). EBUS-TBCB was more sensitive to both malignant and inflammatory diseases. EBUS-TBCB produced 6 mild complications resolved during the same procedure.
Conclusions:
EBUS-TBCB is a cost-effective and safe technique superior to EBUS-TBNA. Future studies could confirm our findings.
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