Particulate matter and inflammatory skin diseases: From epidemiological and mechanistic studies

Epidemiological and toxicological studies have confirmed that exposure to atmospheric particulate matter (PM) could affect our cardiovascular and respiratory systems. Recent studies have shown that PM can penetrate the skin and cause skin inflammation, but the evidence is limited and contradictory. As the largest outermost surface of the human body, the skin is constantly exposed to the environment. The aim of this study was to assess the relationship between PM and inflammatory skin diseases. Most epidemiological studies have provided positive evidence for outdoor, indoor, and wildfire PM and inflammatory skin diseases. The effects of PM exposure during pregnancy and inflammatory skin diseases in offspring are heterogeneous. Skin barrier dysfunction, Oxidative stress, and inflammation may play a critical role in the underlying mechanisms. Finally, we summarize some interventions to alleviate PM-induced inflammatory skin diseases, which may contribute to public health welfare. Overall, PM is related to inflammatory skin diseases via skin barrier dysfunction, oxidative stress, and inflammation. Appropriate government interventions are beneficial.