Related Experiment Video
Updated: Jul 16, 2025

Recording Behavioral Responses to Reflection in Crayfish
Published on: May 14, 2010
Take a walk on the KRAB side
Olga Rosspopoff1, Didier Trono1
1School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Abstract:
Canonical Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) act as major repressors of transposable elements (TEs) via the KRAB-mediated recruitment of the heterochromatin scaffold KRAB-associated protein (KAP)1. KZFP genes emerged some 420 million years ago in the last common ancestor of coelacanth, lungfish, and tetrapods, and dramatically expanded to give rise to lineage-specific repertoires in contemporary species paralleling their TE load and turnover. However, the KRAB domain displays sequence and function variations that reveal repeated diversions from a linear TE-KZFP trajectory. This Review summarizes current knowledge on the evolution of KZFPs and discusses how ancestral noncanonical KZFPs endowed with variant KRAB, SCAN or DUF3669 domains have been utilized to achieve KAP1-independent functions.
More Related Videos
Related Concept Videos
Rab Cascades
Robbers Cave
Actin Treadmilling
The Phragmoplast
The...
Adjusting a Traverse
Red Algae

