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Cefixime disk susceptibility test criteria.

P C Fuchs, A L Barry, R N Jones

    Journal of Clinical Microbiology
    |October 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

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    The 5-microgram cefixime disk test effectively determines bacterial susceptibility. This method offers reliable results for guiding antibiotic treatment decisions in clinical settings.

    Area of Science:

    • Microbiology
    • Clinical Pharmacology

    Background:

    • Cefixime is a third-generation cephalosporin antibiotic used to treat various bacterial infections.
    • Accurate susceptibility testing is crucial for effective antibiotic therapy and preventing antimicrobial resistance.

    Purpose of the Study:

    • To evaluate the efficacy of different cefixime disk strengths (5-, 10-, and 30-microgram) for bacterial susceptibility testing.
    • To determine the optimal disk strength and interpretive criteria for cefixime disk agar diffusion.

    Main Methods:

    • Broth microdilution was used as the reference method to determine minimum inhibitory concentrations (MICs).
    • Disk agar diffusion was performed using 5-, 10-, and 30-microgram cefixime disks on 583 bacterial isolates.
    • MIC breakpoints were set at ≤1.0 µg/ml for susceptible and ≥4 µg/ml for resistant.

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    Main Results:

    • The 5-microgram cefixime disk demonstrated slightly better discrimination between susceptible and resistant isolates compared to other disk strengths.
    • Proposed interpretive criteria for the 5-microgram disk: ≤17 mm (resistant), 18–20 mm (intermediate), and ≥21 mm (susceptible).

    Conclusions:

    • The 5-microgram cefixime disk diffusion test is a reliable method for assessing bacterial susceptibility to cefixime.
    • The recommended interpretive criteria provide a standardized approach for clinical laboratories to interpret cefixime disk diffusion results.