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Micropatterning and Assembly of 3D Microvessels
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In vitro microvascular engineering approaches and strategies for interstitial tissue integration.

A R Murphy1, M C Allenby2

  • 1School of Chemical Engineering, Faculty of Engineering, Architecture and Information Technology, The University of Queensland, St Lucia, QLD 4100, Australia.

Acta Biomaterialia
|September 17, 2023
PubMed
Summary

Lab-grown tissues face challenges in clinical use due to poor vascularization. This review explores methods to engineer functional blood vessel networks within engineered tissues for better nutrient delivery and viability.

Keywords:
BiofabricationIn vitroOrganoidsTissueVascularisationVessels

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • The demand for organ transplants outstrips supply, driving interest in lab-grown tissues.
  • Clinical translation of engineered tissues is hindered by inadequate vascularization for nutrient and waste exchange.
  • Existing tissue engineering methods struggle to integrate vascular networks within dense tissues.

Purpose of the Study:

  • To review advances in engineering vascular structures for lab-grown tissues.
  • To summarize strategies for integrating vascular networks into engineered tissue constructs.
  • To address the challenge of fabricating large-scale vascularized tissues.

Main Methods:

  • Exploration of vessel morphogenic phenomena crucial for tissue-vascular co-development.
  • Evaluation of recent laboratory techniques for engineering vasculature.
  • Review of approaches for integrating vascular networks with avascular tissue structures.

Main Results:

  • Significant progress has been made in developing in vitro vascular networks.
  • Integrating these networks into dense parenchymal tissues remains a key challenge.
  • Recent approaches show promise in creating vascularized tissue constructs.

Conclusions:

  • Effective vascularization is critical for the survival and function of engineered tissues.
  • Integrating perfusable vascular networks with engineered tissue is a complex spatial and temporal challenge.
  • Further research is needed to surmount integration challenges for clinical applications.