Related Experiment Video
Updated: Jul 16, 2025
06:51
Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents
Published on: August 10, 2018
7.7K
ARL15 and its Multiple Disease Association: Emerging Functions and Potential Therapeutic Application
Manisha Saini1, Varnita Anand1, Aditya Sharma2
1Department of Biochemistry, University of Delhi South Campus, New Delhi 110021, India.
Current Protein & Peptide Science
|September 18, 2023
Summary
The Arf-like 15 (ARL15) protein, a small GTPase, is linked to metabolic diseases like diabetes and rheumatoid arthritis. Further research highlights ARL15 as a potential therapeutic target for these conditions.
Area of Science:
- Biochemistry
- Genetics
- Molecular Biology
Background:
- ARL15 is a RAS superfamily small GTPase with unknown physiological functions.
- Genetic studies link ARL15 variants to metabolic traits, diabetes, rheumatoid arthritis, and lipid disorders.
- Understanding ARL15's role is crucial for metabolic disease research.
Purpose of the Study:
- To elucidate the unique features of the ARL15 small G protein.
- To explore ARL15's association with metabolic and lifestyle diseases.
- To identify ARL15 as a potential therapeutic target for metabolic disorders.
Main Methods:
- Literature review of genetic association studies.
- Analysis of ARL15's known functions in cellular processes.
- Identification of ARL15 binding partners.
Main Results:
- ARL15 participates in vesicular and lipid trafficking.
- Several binding partners of ARL15 have been identified.
- ARL15 variants are statistically associated with complex diseases.
Conclusions:
- ARL15 is implicated in various metabolic and lifestyle diseases.
- ARL15 presents a promising therapeutic target for cardiovascular diseases, diabetes, and rheumatoid arthritis.
- Focused research on ARL15 could lead to novel treatments for rheumatoid arthritis.
