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Hypocomplementemic urticarial vasculitis syndrome responsive to dapsone.

J S Fortson, J J Zone, M E Hammond

Journal of the American Academy of Dermatology

|November 1, 1986

Summary

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Dapsone effectively treated a patient with urticarial vasculitis, polyarthritis, glomerulonephritis, and COPD. This case highlights dapsone

Area of Science:

Rheumatology
Nephrology
Pulmonology

Background:

Urticarial vasculitis is a condition characterized by inflammation of blood vessels.
It can affect multiple organ systems, leading to significant morbidity.

Observation:

A 45-year-old woman presented with urticaria-like skin lesions, progressing to polyarthritis, glomerulonephritis, and chronic obstructive pulmonary disease.
Skin biopsy revealed leukocytoclastic vasculitis; kidney biopsy showed mesangioproliferative glomerulonephritis; lung biopsy indicated severe emphysema and vascular immunoglobulin deposition.

Findings:

Dapsone therapy resulted in marked improvement of both cutaneous vasculitis and arthritis.
The case underscores the potential for severe pulmonary and renal complications in this syndrome.

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Implications:

This case demonstrates the therapeutic efficacy of dapsone in managing both the cutaneous and arthritic manifestations of urticarial vasculitis.
It emphasizes the importance of considering systemic involvement and prompt treatment to prevent severe organ damage.