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Related Concept Videos

Pericarditis III: Medical Management01:17

Pericarditis III: Medical Management

13
The primary objectives of managing pericarditis are to determine the underlying cause, provide effective therapy for treatment and symptom relief, and promptly detect signs and symptoms of cardiac tamponade. The following outlines the essential aspects of medical management for pericarditis:ObjectivesDetermine the Cause: Identifying the underlying cause of pericarditis is crucial for targeted treatment. Causes include viral infections, autoimmune diseases, post-cardiac injury syndrome, and...
13
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

11
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
11
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

12
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
12
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

7
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
7
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

9
Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
9
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

9
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
9

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Related Experiment Video

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Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
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Mesalazine-induced myopericarditis: a case series.

Valentina Andrei1,2, Nicoletta D'Ettore1,2, Valentina Scheggi2,3

  • 1Division of Structural Interventional Cardiology, University Hospital Careggi, Largo Brambilla 3, 50133 Florence, Italy.

European Heart Journal. Case Reports
|September 18, 2023
PubMed
Summary

Mesalazine (5-ASA), a common inflammatory bowel disease (IBD) treatment, can rarely cause life-threatening heart inflammation (myopericarditis). Early recognition and discontinuation are crucial for patient recovery.

Keywords:
5-ASACardiotoxicityCase seriesInflammatory bowel diseasesMesalazineMyopericarditis

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Area of Science:

  • Cardiology
  • Gastroenterology
  • Pharmacology

Background:

  • Inflammatory bowel diseases (IBD) involve chronic gastrointestinal inflammation with potential multiorgan effects.
  • Mesalazine (5-ASA) is a primary therapeutic agent for IBD.
  • Mesalazine is associated with rare but severe cardiac side effects.

Observation:

  • Two cases of myopericarditis attributed to 5-ASA hypersensitivity are presented.
  • Cardiac magnetic resonance imaging confirmed myopericarditis in both patients.
  • One patient with ulcerative colitis improved after 5-ASA discontinuation; a second patient developed heart failure symptoms post-5-ASA initiation.

Findings:

  • Mesalazine hypersensitivity can manifest as myopericarditis.
  • Distinguishing 5-ASA-induced cardiac injury from IBD-related inflammation is clinically challenging.
  • Prompt recognition of 5-ASA cardiotoxicity is essential.

Implications:

  • Clinicians should consider 5-ASA hypersensitivity in IBD patients presenting with cardiac symptoms.
  • Cardiac monitoring may be warranted for patients on long-term 5-ASA therapy.
  • This highlights the importance of a thorough medication review in managing complex IBD cases.