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Common microRNA regulated pathways in Alzheimer's and Parkinson's disease

Betina Awuson-David1, Adrian C Williams2, Benjamin Wright2

  • 1School of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham, United Kingdom.

Frontiers in Neuroscience
|September 18, 2023
PubMed

Insights

MicroRNAs (miRNAs) are implicated in Alzheimer's and Parkinson's diseases. This study identified common miRNA pathways and potential blood biomarkers, like let-7f-5p and miR-29b-3p, for Parkinson's disease diagnosis.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are key regulators of gene expression.
  • Dysregulation of miRNAs is increasingly linked to neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD).
  • Current diagnostic methods for AD and PD are often late-stage, highlighting the need for early detection and novel therapeutic targets.

Purpose of the Study:

  • To identify common molecular mechanisms and potential therapeutic targets shared between Alzheimer's disease and Parkinson's disease by analyzing miRNA dysregulation.
  • To explore the utility of blood-based miRNAs as biomarkers for neurodegenerative diseases.

Main Methods:

  • Conducted two independent systematic reviews to collate existing literature on miRNA dysregulation in AD and PD.
  • Performed bioinformatic analysis to identify common miRNAs and pathways (KEGG) between the two diseases.
  • Validated the expression of selected common miRNAs in a small cohort of AD and PD patients.

Main Results:

  • Identified 15 common miRNAs and 13 common KEGG pathways implicated in both AD and PD.
  • The miRNAs let-7f-5p and miR-29b-3p were found to be significantly dysregulated.
  • Let-7f-5p and miR-29b-3p demonstrated potential as predictive biomarkers in the blood of Parkinson's disease patients.

Conclusions:

  • Alzheimer's disease and Parkinson's disease share common underlying miRNA-mediated biological pathways.
  • Specific miRNAs, such as let-7f-5p and miR-29b-3p, may serve as valuable blood-based biomarkers for Parkinson's disease.
  • Further research into these common pathways could lead to the development of novel, shared therapeutic strategies for neurodegenerative diseases.
Keywords:
Alzheimer’s diseaseParkinson’s diseasebiomarkersmicroRNAneurodegenerationtherapeutic targets

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