Cell electrospinning and its application in wound healing: principles, techniques and prospects

Area of Science:

• Biomaterials Science
• Tissue Engineering
• Regenerative Medicine

Background:

• Current wound healing clinical strategies face limitations in achieving rapid and effective tissue regeneration.
• Traditional electrospinning (ES) creates scaffolds but lacks the integration of living cells for enhanced repair.
• There is a need for advanced biomaterial scaffolds that actively promote cellular integration and tissue reconstruction.

Purpose of the Study:

• To review and summarize cell electrospinning (C-ES) technology for wound healing applications.
• To highlight the advantages of C-ES over traditional ES, focusing on cytoactivity and scaffold design.
• To discuss the potential of C-ES in biomaterials and cell applications for tissue repair.

Main Methods:

• Review of existing literature on cell electrospinning (C-ES) techniques and applications.
• Analysis of parameters critical for maintaining cell viability during the electrospinning process.
• Evaluation of material selection and scaffold design considerations for C-ES.

Main Results:

• Cell electrospinning (C-ES) enables the encapsulation of living cells within 3D fiber scaffolds, creating a conducive microenvironment for tissue repair.
• C-ES offers distinct advantages over traditional ES by actively incorporating cellular components, leading to enhanced tissue regeneration.
• Key parameters for maintaining cell activity and appropriate material choices are crucial for successful C-ES scaffold development.

Conclusions:

• Cell electrospinning (C-ES) presents a promising advanced technology for promoting rapid and effective wound healing.
• Further research into optimizing C-ES methods and materials can overcome current limitations and expand its clinical utility.
• C-ES holds significant potential for revolutionizing tissue engineering and regenerative medicine applications in wound care.