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Recurring renal lithiasis due to Dent's disease
Miquel Amer-Mestre1, Jordi Guimerà-García1, Ricardo Guldris-García1
1Urology Department, Son Espases University Hospital, Carretera Valldemossa, 79, 07120, Palma, Balearic Islands, Spain.
Urology Case Reports
|September 18, 2023
Summary
Dent's disease, a rare condition causing high calcium in urine (hypercalciuria) and kidney stones, involves elevated bone resorption. This case study shows stability with percutaneous nephrolithotomy and medical treatment.
Area of Science:
- Nephrology
- Endocrinology
- Genetics
Background:
- Dent's disease is a rare genetic disorder.
- It is characterized by hypercalciuria, nephrocalcinosis, and kidney stones.
- Pathological bone resorption is a key feature, linked to urinary parathormone (PTH).
Observation:
- A 21-year-old male presented with recurrent bilateral kidney stones.
- He exhibited hypercalciuria and elevated bone resorption markers.
- The patient's condition was associated with suspected Dent's disease.
Findings:
- Percutaneous nephrolithotomy (PNL) was performed to remove kidney stones.
- Medical management included hydrochlorothiazide, potassium-citrate, and phytate.
- This combined approach led to radiological and clinical stability.
Implications:
- This case highlights a successful treatment strategy for Dent's disease.
- It demonstrates the efficacy of PNL combined with specific medical therapies.
- Further research into managing bone resorption in Dent's disease is warranted.
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