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Related Concept Videos

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Mitral Regurgitation I: Introduction

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Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
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Related Experiment Video

Updated: Jul 16, 2025

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

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Sex differences in right ventricular function between Groups 1 and 3 pulmonary hypertension.

Felipe Kazmirczak1, Thenappan Thenappan1, Kurt W Prins1

  • 1Cardiovascular Division, Department of Medicine, Lillehei Heart Institute University of Minnesota Minneapolis Minnesota USA.

Pulmonary Circulation
|September 18, 2023
PubMed
Summary

Group 3 pulmonary hypertension patients show more right ventricular dysfunction than pulmonary arterial hypertension patients. This difference in right ventricular dysfunction may be linked to a higher proportion of males in Group 3 pulmonary hypertension.

Keywords:
echocardiographyright ventricle function and dysfunctionsex differences

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Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Echocardiography

Background:

  • Group 3 pulmonary hypertension (PH) is associated with greater right ventricular dysfunction (RVD) compared to pulmonary arterial hypertension (PAH).
  • Understanding factors modulating RVD in different PH groups is crucial for patient management.

Purpose of the Study:

  • To investigate the influence of sex and PH etiology on the severity of RVD.
  • To compare RVD between Group 3 PH and PAH, considering sex-specific differences.

Main Methods:

  • Utilized strain echocardiography to assess RVD.
  • Analyzed data stratified by PH group (Group 3 PH vs. PAH) and sex.

Main Results:

  • No significant intrasex differences in RVD were observed between Group 3 PH and PAH.
  • Right ventricular dysfunction appears heightened in Group 3 PH, irrespective of sex within the analyzed groups.

Conclusions:

  • The increased RVD in Group 3 PH may be attributed to a higher prevalence of males in this patient cohort.
  • Further research is needed to elucidate the complex interplay between sex, etiology, and RVD in pulmonary hypertension.