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Updated: Jul 16, 2025

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
Published on: May 10, 2021
Focusing on the Native Matrix Proteins in Calcific Aortic Valve Stenosis
Nikolaos Anousakis-Vlachochristou1, Dimitra Athanasiadou2, Karina M M Carneiro2,3
1National and Kapodistrian University of Athens, Medical School, First Department of Cardiology, Athens, Greece.
Abstract:
Calcific aortic valve stenosis (CAVS) is a widespread valvular heart disease affecting people in aging societies, primarily characterized by fibrosis, inflammation, and progressive calcification, leading to valve orifice stenosis. Understanding the factors associated with CAVS onset and progression is crucial to develop effective future pharmaceutical therapies. In CAVS, native extracellular matrix proteins modifications, play a significant role in calcification in vitro and in vivo. This work aimed to review the evidence on the alterations of structural native extracellular matrix proteins involved in calcification development during CAVS and highlight its link to deregulated biomechanical function.
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