Related Experiment Video

Updated: Jul 15, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction
05:26

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Myocardial specific creatine phosphokinase isoenzyme elevation in children with asthma treated with intravenous

J F Maguire, R S Geha, D T Umetsu

    The Journal of Allergy and Clinical Immunology
    |October 1, 1986
    PubMed

    Insights

    Intravenous isoproterenol for severe childhood asthma may elevate cardiac enzymes, suggesting potential myocardial injury. Monitoring creatine phosphokinase MB (CPK-MB) is recommended during this treatment.

    Area of Science:

    • Pediatric Critical Care
    • Cardiology
    • Pulmonology

    Background:

    • Severe childhood asthma (status asthmaticus) is a critical condition requiring intensive care.
    • Intravenous (IV) isoproterenol has been used in managing severe asthma.
    • Potential cardiac side effects of asthma medications require careful evaluation.

    Purpose of the Study:

    • To investigate the association between IV isoproterenol use and cardiac enzyme elevation in children with severe asthma.
    • To determine if elevated cardiac enzymes indicate myocardial injury during this therapy.

    Main Methods:

    • Retrospective review of intensive care unit admissions for severe childhood status asthmaticus.
    • Analysis of serum creatine phosphokinase MB (CPK-MB) levels in patients receiving IV isoproterenol.
    • Comparison of CPK-MB levels before and after discontinuation of IV isoproterenol.

    Main Results:

    • Elevated CPK-MB levels were observed in 15 out of 19 admissions (79%).
    • Mean peak CPK-MB elevation was 204 IU/L with a mean peak MB band of 6.05%.
    • CPK-MB levels normalized in all 9 patients after IV isoproterenol was stopped, even with continued other asthma therapies.

    Conclusions:

    • Elevated serum CPK-MB levels in children treated with IV isoproterenol for severe asthma may indicate myocardial injury.
    • Caution and serial monitoring of CPK-MB levels are recommended when using IV isoproterenol in pediatric asthma management.

    More Related Videos

    Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training07:40

    Impact of High-intensity Interval Exercise and Moderate-Intensity Continuous Exercise on the Cardiac Troponin T Level at an Early Stage of Training

    Published on: October 10, 2019

    Measurement of Myocardial Lactate Production for Diagnosis of Coronary Microvascular Spasm06:18

    Measurement of Myocardial Lactate Production for Diagnosis of Coronary Microvascular Spasm

    Published on: September 17, 2021

    Related Concept Videos

    Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

    Blood Studies for Cardiovascular System I: Cardiac Biomarkers

    Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
    The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
    Troponins
    Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
    Myocarditis II: Clinical Features and Diagnostic Tests01:27

    Myocarditis II: Clinical Features and Diagnostic Tests

    Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
    Myocarditis III: Medical Management01:14

    Myocarditis III: Medical Management

    Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
    Myocarditis IV: Nursing Management01:22

    Myocarditis IV: Nursing Management

    Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
    Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

    Cardiomyopathy III: Hypertrophic Cardiomyopathy

    Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
    Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

    Cardiomyopathy IV: Restrictive Cardiomyopathy

    Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...