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Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

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Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
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Nephrons01:10

Nephrons

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The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
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Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

34
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
34
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

33
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
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Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

19
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
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Updated: Jul 16, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
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5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

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COVID-19-Associated Nephropathy: A Devastating Complication.

Andrew Kim1, Abdullahi Mahgoub1, Abinash Parajuli1

  • 1Internal Medicine, Hurley Medical Center/Michigan State University College of Human Medicine, Flint, USA.

Cureus
|September 18, 2023
PubMed
Summary
This summary is machine-generated.

COVID-19-associated nephropathy (COVAN) involves collapsing focal segmental glomerulosclerosis (cFSGS). This case report highlights the need for more research into COVAN

Keywords:
collapsing fsgscovancovid-19glomerulosclerosisnephropathynephroticsars-cov-2

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Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pathophysiology

Background:

  • The emergence of SARS-CoV-2 has led to the identification of COVID-19-associated nephropathy (COVAN).
  • COVAN is characterized by collapsing focal segmental glomerulosclerosis (cFSGS), necessitating research into its underlying mechanisms.

Observation:

  • This case report details a 77-year-old patient with COVID-19 infection and biopsy-confirmed cFSGS.
  • The case contributes to the growing body of evidence linking SARS-CoV-2 infection with cFSGS.

Findings:

  • Current treatment guidelines for COVAN mirror those for other cFSGS etiologies.
  • Existing treatments for COVAN demonstrate poor outcomes and resistance, indicating a need for novel therapeutic strategies.

Implications:

  • Further investigation into the clinical assessment and pathophysiology of COVAN is crucial.
  • Enhanced understanding is required to develop timely and effective interventions for COVAN patients.