Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Formulation of controlled-release products.

J R Robinson, L J Gauger

    The Journal of Allergy and Clinical Immunology
    |October 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Test-retest reliability of the two-point discrimination test on the sole of the foot in people with multiple sclerosis.

    Physiological measurement·2020
    Same author

    The Avon patellofemoral joint arthroplasty: two- to 18-year results of a large single-centre cohort.

    The bone & joint journal·2018
    Same author

    Survivorship and clinical outcome of the minimally invasive Uniglide medial fixed bearing, all-polyethylene tibia, unicompartmental knee arthroplasty at a mean follow-up of 7.3years.

    The Knee·2016
    Same author

    Dropped Gallstones Causing a Perihepatic Abscess and Empyema.

    Case reports in surgery·2015
    Same author

    Bristol index of patellar width to thickness (BIPWiT): a reproducible measure of patellar thickness from adult MRI.

    The Knee·2014
    Same author

    Do long leg supine CT scanograms correlate with weight-bearing full-length radiographs to measure lower limb coronal alignment?

    The Knee·2013

    This paper reviews controlled drug delivery systems, focusing on prolonged-release theophylline products. It highlights the empirical nature of product development and the need for better clinical validation for sustained-release medications.

    Area of Science:

    • Pharmacology
    • Drug Delivery Systems

    Background:

    • Numerous prolonged-release theophylline products exist, each with unique claims.
    • The field of controlled drug delivery has a long history but is still developing a strong theoretical and clinical foundation.

    Purpose of the Study:

    • To provide an overview of controlled drug delivery.
    • To discuss the characteristics of available sustained- or controlled-release theophylline products.

    Main Methods:

    • Review of theoretical principles in controlled drug delivery.
    • Analysis of biologic constraints for oral administration.
    • Overview of current sustained- and controlled-release product types.

    Main Results:

    • Many sustained-release products are developed empirically.

    Related Experiment Videos

  • Clinical testing in healthy volunteers may not reflect real-world performance.
  • Controlled drug delivery is an emerging discipline with a growing theoretical and clinical base.

    • Conclusions:

    • The development of sustained-release theophylline products often relies on empirical methods.
    • There is a need for improved clinical relevance in the testing of these drug delivery systems.
    • Controlled drug delivery is advancing as a scientifically-grounded field.