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Related Experiment Video

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High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
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The Contin delivery system: dosing considerations.

S Leslie

    The Journal of Allergy and Clinical Immunology
    |October 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Once-daily Uniphyl (anhydrous theophylline) tablets offer sustained theophylline delivery, comparable to twice-daily dosing. Evening administration may improve morning lung function in asthma patients.

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    Area of Science:

    • Pharmacology
    • Drug Delivery Systems

    Background:

    • The Contin delivery system utilizes hydrated cellulose and higher aliphatic alcohols for sustained-release formulations.
    • This system is employed for drugs like aminophylline, theophylline, and morphine.

    Purpose of the Study:

    • To evaluate the clinical and pharmacokinetic profile of once-daily Uniphyl (anhydrous theophylline) 400 mg tablets.
    • To assess the impact of food intake on the absorption of once-daily theophylline.
    • To investigate the potential benefits of evening administration for asthma patients experiencing morning bronchoconstriction.

    Main Methods:

    • Clinical and pharmacokinetic evaluations of Uniphyl 400 mg tablets.
    • Studies involving volunteers and patients with varying food intake.
    • Comparison of once-daily versus twice-daily theophylline dosing regimens.

    Main Results:

    • Once-daily morning dosing of Uniphyl was found to be equivalent to twice-daily theophylline administration.
    • High-calorie, high-fat meals increased theophylline absorption without dose-dumping.
    • Pharmacokinetic evaluations in patients yielded comparable bioavailability to twice-daily theophylline.
    • Evening administration of Uniphyl in asthma patients improved morning pulmonary function compared to twice-daily dosing.

    Conclusions:

    • Once-daily Uniphyl provides effective sustained-release theophylline delivery.
    • Food intake can enhance the absorption of once-daily theophylline without adverse effects.
    • Evening administration of once-daily theophylline may be a beneficial strategy to mitigate morning dips in lung function for asthma patients.