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Denosumab Use in Chronic Kidney Disease Associated Osteoporosis: A Narrative Review

Abduelmula R Abduelkarem1,2, Adnane Guella3, Amar M Hamrouni4

  • 1Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah, United Arab Emirates.

Risk Management and Healthcare Policy
|September 18, 2023
PubMed

Insights

Denosumab effectively manages bone disease in chronic kidney disease (CKD) patients on hemodialysis (HD). This treatment reduces fracture risk and improves bone mineral density, offering a promising therapeutic option for this vulnerable population.

Area of Science:

  • Nephrology
  • Endocrinology
  • Orthopedics

Background:

  • Chronic kidney disease (CKD) and hemodialysis (HD) patients face high rates of bone disease and fracture.
  • Effective management of bone health is a significant clinical challenge in this population.

Purpose of the Study:

  • To review the current evidence on the efficacy and safety of denosumab in CKD and HD patients.
  • To assess denosumab's impact on bone health outcomes in patients with kidney disease.

Main Methods:

  • Comprehensive literature search including randomized controlled trials, observational studies, and meta-analyses.
  • Systematic review of studies investigating denosumab in CKD and HD populations.

Main Results:

  • Denosumab demonstrated a reduction in fracture risk across all stages of CKD.
  • Improvements in bone mineral density were observed in patients treated with denosumab.
  • Evidence suggests a favorable safety profile for denosumab in this cohort.

Conclusions:

  • Denosumab is a promising therapeutic option for managing bone disease in CKD and HD patients.
  • The findings support the use of denosumab for improving bone health and reducing fractures in this patient group.

Keywords:
bone diseasechronic kidney diseasedenosumabfracture risk reductionhemodialysis

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