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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

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Non-coding RNAs are key players and promising therapeutic targets in atherosclerosis

Zhun Yu1, JinZhu Yin2, ZhiTong Tang3

  • 1School of Clinical Medical, Changchun University of Chinese Medicine, Jilin, China.

Frontiers in Cell and Developmental Biology
|September 18, 2023
PubMed

Insights

Noncoding RNAs (ncRNAs) are key regulators in atherosclerosis (AS) development. Research shows ncRNAs can serve as diagnostic markers and therapeutic targets for this common cardiovascular disease.

Area of Science:

  • Biochemistry
  • Genetics
  • Molecular Biology

Background:

  • Cardiovascular disease (CVD), primarily atherosclerosis (AS), is a leading cause of human mortality.
  • The complex pathogenesis and numerous risk factors of AS are not fully understood.
  • Noncoding RNAs (ncRNAs) are crucial epigenetic regulators involved in gene expression networks.

Purpose of the Study:

  • To review the role of ncRNAs in the development of atherosclerosis.
  • To explore the potential of ncRNAs as diagnostic markers for AS.
  • To examine ncRNAs as targets for novel AS-targeted therapies.

Main Methods:

  • Literature review of studies on ncRNAs and atherosclerosis.
  • Analysis of evidence for ncRNA involvement in AS pathogenesis.
  • Evaluation of ncRNAs as biomarkers and therapeutic targets.

Main Results:

  • ncRNAs are implicated in all stages of AS, from initiation to progression.
  • Specific ncRNAs exhibit differential expression patterns during AS development.
  • ncRNAs demonstrate potential as sensitive diagnostic markers for AS screening.

Conclusions:

  • ncRNAs play a significant role in the pathogenesis of atherosclerosis.
  • ncRNAs represent promising diagnostic biomarkers for early AS detection.
  • Targeting ncRNAs offers a potential therapeutic strategy for managing AS.

Keywords:
atherosclerosiscardiovascular diseasemiRNAsncRNAstargeted therapy of atherosclerosis

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