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Updated: Jul 16, 2025
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Plasma myeloperoxidase: association with atrial fibrillation progression and recurrence after catheter ablation
Jingmeng Liu1, Changjian Lin1, Taojie Zhou1
1Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background:
Myeloperoxidase (MPO), released by activated neutrophils, is significantly increased in atrial fibrillation (AF). MPO may play a role in the progression of atrial fibrillation and further involved in AF recurrence after catheter ablation. We compared plasma MPO levels in paroxysmal and persistent AF and explored their role in AF recurrence after catheter ablation.
Methods:
Plasma MPO levels were measured in consecutive patients with paroxysmal AF (n = 225) and persistent AF (n = 106). Samples of patients were collected from the femoral vein during catheter ablation and all patients included were followed up after catheter ablation.
Results:
Plasma MPO levels increased from paroxysmal AF to persistent AF patients (56.31 [40.33-73.51] vs. 64.11 [48.65-81.11] ng/ml, p < 0.001). MPO significantly correlated with left atrium volume (LAV) and there existed a significant interaction between the two in relation to AF recurrence (p for interaction <0.05). During a median follow-up of 14 months, 28 patients with paroxysmal AF (12.44%) and 27 patients with persistent AF (25.47%) presented with recurrence after catheter ablation. The percentage of recurrence increased stepwise with increasing tertiles of MPO levels in both paroxysmal AF and persistent AF. MPO levels remained independently associated with AF recurrence after adjusting for potential confounding variables.
Conclusion:
MPO levels were higher in persistent AF than in paroxysmal AF and MPO was positively correlated with LAV in AF. Elevated MPO levels may predispose a switch in AF phenotype and AF recurrence after catheter ablation.
Insights
Higher myeloperoxidase (MPO) levels are linked to persistent atrial fibrillation (AF) and increased AF recurrence after catheter ablation. MPO may drive AF progression and recurrence risk.
Area of Science:
- Cardiology
- Biomarkers
- Electrophysiology
Background:
- Myeloperoxidase (MPO) is elevated in atrial fibrillation (AF) and may contribute to its progression.
- MPO's role in AF recurrence post-catheter ablation requires further investigation.
Purpose of the Study:
- To compare plasma MPO levels in paroxysmal and persistent AF.
- To explore the association between MPO levels and AF recurrence after catheter ablation.
Main Methods:
- Plasma MPO levels were measured in 225 paroxysmal AF and 106 persistent AF patients.
- Patients were followed up post-catheter ablation to assess AF recurrence.
Main Results:
- MPO levels were significantly higher in persistent AF than paroxysmal AF (p < 0.001).
- MPO correlated with left atrium volume (LAV) and predicted AF recurrence independently.
- Recurrence rates increased with higher MPO tertiles in both AF types.
Conclusions:
- Elevated MPO levels are associated with persistent AF and increased AF recurrence post-ablation.
- MPO may influence AF phenotype and predict recurrence risk.
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