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Updated: Jul 16, 2025

Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
Global effects of aging on the hemodynamic response function in the human brain
Nooshin J Fesharaki1, Amanda Taylor1, Keisjon Mosby1
1Baylor College of Medicine.
Normal aging affects cerebral hemodynamics, impacting functional magnetic resonance imaging (fMRI) studies. This research reveals age-related changes in hemodynamic response function (HRF) parameters, suggesting HRF as a potential biomarker for aging.
Area of Science:
- Neuroimaging
- Cognitive Neuroscience
- Vascular Biology
Background:
- Functional magnetic resonance imaging (fMRI) relies on the hemodynamic response function (HRF) to infer neural activity.
- Interpreting fMRI data in cognitive aging studies often assumes HRF is stable, attributing activation differences solely to neural changes.
- Emerging evidence suggests normal aging impacts cerebral vasculature and hemodynamics, potentially confounding fMRI interpretations in aging research.
Conclusions:
- Normal aging significantly alters hemodynamic response function (HRF) characteristics.
- HRF parameters exhibit age-dependent variations, independent of neural activity changes.
- HRF analysis holds promise as a sensitive biomarker for detecting age-related vascular and metabolic pathology.
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