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Related Experiment Videos

Vitamin E absorption in small premature infants.

E F Bell, E J Brown, R Milner

    Pediatrics
    |June 1, 1979
    PubMed
    Summary
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    Oral vitamin E (dl-alpha tocopherol) therapy effectively corrects deficiency in premature infants. This treatment ensures sustained normal plasma tocopherol levels, demonstrating the efficacy of oral supplementation alone.

    Area of Science:

    • Neonatology
    • Nutritional Science
    • Biochemistry

    Background:

    • Premature infants (<1.5 kg birth weight) are susceptible to vitamin E deficiency.
    • Vitamin E is crucial for infant development and antioxidant protection.
    • Established methods for correcting deficiency in this population are critical.

    Purpose of the Study:

    • To evaluate the efficacy of oral vitamin E administration in premature infants.
    • To determine if oral therapy alone can correct vitamin E deficiency.
    • To assess plasma tocopherol levels following supplementation.

    Main Methods:

    • Orogastric administration of dl-alpha tocopherol or its acetate form.
    • A second blind trial involving 28 infants receiving 25 units of dl-alpha tocopherol or placebo for six weeks.

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  • Plasma tocopherol level monitoring.

    • Main Results:

    • Oral administration of dl-alpha tocopherol increased plasma tocopherol levels.
    • All infants receiving vitamin E supplementation maintained normal adult plasma tocopherol ranges.
    • Oral therapy alone proved sufficient for correcting vitamin E deficiency.

    Conclusions:

    • Oral vitamin E therapy is an effective method for correcting vitamin E deficiency in premature infants.
    • Sustained normal plasma tocopherol levels can be achieved with oral supplementation.
    • This approach offers a viable solution for managing vitamin E status in high-risk neonates.