Related Experiment Video

Updated: Jul 16, 2025

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

3.9K

Evaluation of Arterial Stiffness and Subfoveal Choroidal Thickness in Patients with Coronary Slow Flow

Zekeriya Dogan1, Cigdem Ileri2, Beste Ozben1

  • 1Department of Cardiology, Marmara University School of Medicine.

Acta Cardiologica Sinica
|September 18, 2023
PubMed

Insights

Coronary slow flow is linked to increased arterial stiffness and thinner choroid layers, suggesting it may be a sign of a systemic microvascular disorder affecting the entire arterial system.

Area of Science:

  • Cardiovascular Medicine
  • Ophthalmology
  • Vascular Biology

Background:

  • Coronary slow flow (CSF) may indicate a broader arterial system issue, not just localized to coronary arteries.
  • Systemic microvascular dysfunction is increasingly recognized as a contributor to cardiovascular events.

Purpose of the Study:

  • To investigate peripheral arterial stiffness and choroidal thickness in patients with CSF.
  • To explore the relationship between CSF, arterial stiffness, and ocular microvasculature.

Main Methods:

  • Fifty CSF patients and 25 controls underwent coronary angiography.
  • Peripheral arterial stiffness was assessed using the Mobil-O-Graph system.
  • Choroidal thickness was measured via enhanced depth imaging optical coherence tomography.

Main Results:

  • CSF patients exhibited higher peripheral systolic blood pressure, pulse pressure, central pulse pressure, and pulse wave velocity (PWV).
  • CSF patients had significantly thinner choroidal thickness compared to controls.
  • CSF was an independent predictor of increased PWV and reduced choroidal thickness.

Conclusions:

  • Increased peripheral arterial stiffness (PWV) and thinner choroid in CSF patients suggest a systemic microvascular disorder.
  • CSF may represent a coronary manifestation of a widespread vascular issue.
  • Further research into systemic implications of CSF is warranted.
Abstract

Keywords:
Arterial stiffnessChoroidal thicknessCoronary slow flow phenomenon

More Related Videos

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

15.0K
Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

1.8K

Related Concept Videos

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
15
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
13
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
9
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
13
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
12