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Staphylococcal infections in aging mice.

D B Louria, M A Lavenhar, T Kaminski

    Journal of Gerontology
    |November 1, 1986
    PubMed
    Summary
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    Aging impairs the immune response to Staphylococcus infection, leading to higher mortality in older mice due to reduced bacterial clearance and increased toxin sensitivity.

    Area of Science:

    • Immunology
    • Microbiology
    • Gerontology

    Background:

    • Aging is associated with increased susceptibility to infections.
    • Staphylococcus infections pose a significant health risk, particularly in vulnerable populations.

    Purpose of the Study:

    • To investigate the impact of aging on the host immune response to Staphylococcus infection.
    • To compare the mortality rates and cellular immune mechanisms between young and aging mice.

    Main Methods:

    • Infection of young and aging mice with Staphylococcus.
    • Assessment of 28-day mortality rates.
    • Evaluation of phagocytosis, intracellular killing by leukocytes, and leukocyte mobilization.
    • Administration of staphylococcal toxins and endotoxin to assess lethality.

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    Main Results:

    • Aging mice exhibited a significantly higher 28-day mortality rate (70%) compared to young mice (14.3%).
    • While intracellular killing by polymorphonuclear leukocytes was slightly less effective in older mice, they mobilized twice as many leukocytes.
    • Older mice showed markedly increased susceptibility to staphylococcal toxins and endotoxin.

    Conclusions:

    • Aging compromises the immune system's ability to combat Staphylococcus infection.
    • Increased mortality in aging mice is linked to both impaired cellular immunity and heightened sensitivity to bacterial toxins.