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Predictive Value of Post-Percutaneous Coronary Intervention Quantitative Flow Ratio for Vessel-Oriented Composite
Weibin Liu1, Huaxiu Cai1, Yin Zheng2
1Department of Cardiology, Ganzhou People's Hospital, Ganzhou 341000, China.
Insights
Low post-PCI quantitative flow ratio (QFR) is a significant predictor of vessel-oriented composite endpoints (VOCE) after percutaneous coronary intervention. This finding highlights QFR
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Imaging
Background:
- Accurate prediction of post-percutaneous coronary intervention (PCI) vessel-oriented composite endpoints (VOCE) remains a clinical challenge.
- Quantitative flow ratio (QFR) has emerged as a promising non-invasive imaging biomarker.
- Existing indicators for predicting post-PCI VOCE are limited.
Conclusions:
- Post-PCI QFR demonstrates significant predictive value for vessel-oriented composite endpoints.
- Lower QFR values post-PCI are associated with an increased risk of adverse events.
- QFR can serve as a valuable tool for risk stratification in patients undergoing PCI.
Abstract:
At present, there is a lack of indicators, which can accurately predict the post-percutaneous coronary intervention (post-PCI) vessel-oriented composite endpoint (VOCE). Recent studies showed that the post-PCI quantitative flow ratio (QFR) can predict post-PCI VOCE. PubMed, Embase, and Cochrane were searched from inception to March 27, 2022, and the cohort studies about that the post-PCI QFR predicts post-PCI VOCE were screened. Meta-analysis was performed, including 6 studies involving 4518 target vessels. The results of the studies included in this meta-analysis all showed that low post-PCI QFR was an independent risk factor for post-PCI VOCE after adjusting for other factors, HR (95% CI) ranging from 2.718 (1.347-5.486) to 6.53 (2.70-15.8). Our meta-analysis showed that the risk of post-PCI VOCE was significantly higher in the lower post-PCI QFR group than in the higher post-PCI QFR group (HR: 4.14, 95% CI: 3.00-5.70, P < 0.001, I2 = 27.9%). Post-PCI QFR has a good predictive value for post-PCI VOCE. Trial Registration. This trial is registered with CRD42022322001.
