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Updated: Jul 16, 2025

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Published on: March 15, 2022
Cerebral embolic protection during transcatheter heart interventions
Victor Alfonso Jimenez Diaz1,2, Samir R Kapadia3, Axel Linke4
1Cardiology Department, Hospital Álvaro Cunqueiro, University Hospital of Vigo, Vigo, Spain.
Cerebral embolic protection devices (CEPDs) capture debris during transcatheter aortic valve replacement (TAVR) but haven't yet proven superior for stroke prevention. Further trials are needed to assess CEPDs in TAVR and other procedures.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Biomedical Engineering
Background:
- Stroke is a significant complication of transcatheter aortic valve replacement (TAVR), occurring in approximately 3% of patients.
- Cerebral embolic protection devices (CEPDs) capture embolic debris during TAVR, and imaging studies show they reduce new cerebral lesions.
Conclusions:
- Despite capturing debris, current CEPDs have not demonstrated superiority in preventing TAVR-related strokes in randomized trials.
- Tailored clinical trials are necessary for various CEPD designs and for evaluating their use in non-TAVR procedures.
- Assessing the cost-effectiveness of CEPDs is crucial for global adoption.
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