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Monitoring Patients With Inflammatory Bowel Disease at High Risk of Anal Cancer
Cassandra A Cairns1, Raymond K Cross2, Mariam Khambaty3
1Department of Surgery, Division of General and Oncologic Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Patients with inflammatory bowel disease (IBD) face higher anal cancer risks. This review proposes a new screening strategy to improve early detection in this vulnerable population.
Area of Science:
- Gastroenterology and Oncology
- Focuses on the intersection of inflammatory bowel disease (IBD) and anal cancer epidemiology and management.
Background:
- Inflammatory bowel disease (IBD) patients exhibit elevated risks for adenocarcinoma and human papillomavirus-related squamous cell carcinoma.
- Despite increased risk, standardized screening, diagnosis, and treatment protocols for anal cancer in IBD patients are absent.
Approach:
- Comprehensive review of recent literature on anal cancer within the IBD population.
- Analysis of unique diagnostic and therapeutic challenges specific to IBD patients with anal cancer.
Key Points:
- IBD is linked to higher rates of specific anal cancer types.
- Current management lacks uniform guidelines, posing significant challenges.
- A novel screening approach is suggested for early detection.
Conclusions:
- Early detection of anal cancer in IBD patients is critical.
- A proposed screening motif, informed by literature and clinical expertise, aims to enhance early identification.
- Multidisciplinary collaboration is essential for optimizing care.
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