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Clinical evaluation of Sepsis-1 and Sepsis-3 in infective endocarditis

Qi Wang1, Bingqi Fu1, Peihang Hu2

  • 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510080, China.

International Journal of Cardiology
|September 18, 2023
PubMed

Insights

The Sepsis-3 criteria better predict mortality in infective endocarditis (IE) patients than Sepsis-1. This study found Sepsis-3 independently associated with higher in-hospital and 6-month mortality risks in IE patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Sepsis significantly impacts survival outcomes in infective endocarditis (IE) patients.
  • The predictive value of current sepsis definitions (Sepsis-1 and Sepsis-3) for IE mortality remains unclear.

Purpose of the Study:

  • To evaluate and compare the prognostic performance of Sepsis-1 and Sepsis-3 criteria in predicting mortality among patients with infective endocarditis.

Main Methods:

  • A cohort of 1354 IE patients was analyzed, categorized by Sepsis-1 and Sepsis-3 criteria.
  • Multivariate regression and Kaplan-Meier survival analyses were employed to assess mortality risk prediction.

Main Results:

  • Sepsis-3 identified a higher proportion of patients (36.6%) compared to Sepsis-1 (25.6%).
  • Both criteria significantly correlated with 6-month mortality, but Sepsis-3 demonstrated stronger independent association with in-hospital (OR 2.89) and 6-month mortality (HR 3.24).

Conclusions:

  • The Sepsis-3 criteria exhibit superior predictive performance for mortality risk in infective endocarditis patients compared to Sepsis-1.
  • Sepsis-3 is a more effective tool for risk stratification in IE management.
Abstract

Keywords:
Infective endocarditisPrognosisSepsis

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