Spermidine - an old molecule with a new age-defying immune function.
Kenji Chamoto1, Baihao Zhang2, Masaki Tajima3
1Department of Immunology and Genomic Medicine, Center for Cancer Immunotherapy and Immunobiology, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Immuno-Oncology PDT, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Trends in Cell Biology
|September 18, 2023
Summary
Spermidine, a vital compound, is crucial for immune cell function and fighting cancer. Supplementing spermidine can boost anti-PD-1 therapy effectiveness, especially in aged individuals.
Area of Science:
- Biochemistry
- Immunology
- Metabolomics
Background:
- Polyamines like spermidine regulate key cellular processes.
- Spermidine insufficiency links to aging and cancer development.
- Emerging research highlights spermidine's role in immuno-metabolism and immunotherapy.
Purpose of the Study:
- To review the multifaceted production of spermidine.
- To explore spermidine's impact on immune cell regulation and anticancer immunity.
- To assess spermidine's potential in enhancing immunotherapy efficacy.
Main Methods:
- Review of recent scientific literature on spermidine metabolism and function.
- Analysis of studies on spermidine's role in immune cell activation and antitumor responses.
- Evaluation of spermidine's impact on immunotherapy outcomes in aged models.
Main Results:
- Spermidine is produced via gut bacteria, host-bacteria co-metabolism, and host cells.
- Spermidine enhances antitumor immune responses.
- Spermidine supplementation improves immunotherapy in aged, non-responsive animals.
Conclusions:
- Spermidine is a critical regulator of immune responses and cancer immunity.
- Targeting spermidine production and supplementation offers a novel therapeutic strategy.
- Spermidine supplementation may enhance anti-PD-1 therapy, particularly in aged populations.
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