Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

199
Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
199
Enteral Nutrition I: Orogastric and Nasogastric Feeding01:26

Enteral Nutrition I: Orogastric and Nasogastric Feeding

331
Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
331
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

354
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
354
One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

One-Compartment Open Model for IV Bolus Administration: General Considerations

240
The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant,...
240
Two-Compartment Open Model: IV Bolus Administration01:18

Two-Compartment Open Model: IV Bolus Administration

572
The two-compartment model for intravenous (IV) bolus administration illustrates drug distribution in the body, subdividing it into central and peripheral compartments. This model operates on the concept of two-compartment kinetics. The drug's plasma concentration shows a bi-exponential decline following IV bolus administration, signaling the presence of two disposition processes: distribution and elimination.
The disparity between drug input and the sum of drug transfer rates between...
572
One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance00:56

One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance

102
Clearance is a key pharmacokinetic parameter that quantifies the volume of body fluid from which a drug is entirely removed within a specific time frame. It is crucial in assessing how a drug is eliminated from the body and has critical clinical applications.
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
102

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From surface variability to interaction- and soil-mediated regulation: depth-dependent microbial organization for nitrogen cycling in the dry season in lakeside wetlands.

Journal of environmental management·2026
Same author

Combined regulation of CO<sub>2</sub> and nutrients on carbon fixation and emission of Microcystis aeruginosa: physiological and transcriptomic insights.

Water research·2026
Same author

Pharmacogenomic screening strategy and indicative screening efficiency for antithyroid drug-induced agranulocytosis in the Southern Han Chinese.

European journal of clinical pharmacology·2026
Same author

Electronegativity-correlated selectivity of methanol versus methane in CO<sub>2</sub> photoreduction on doped SnO<sub>2</sub>/TiO<sub>2</sub> S-scheme heterojunctions.

Journal of colloid and interface science·2026
Same author

Correction: Vitamin D levels and prolonged menstrual cycle in women with polycystic ovary syndrome: a cross-sectional study.

Frontiers in nutrition·2026
Same author

Opportunity and risk in achieving food production and conservation goals at high altitude: Evidence from the Tibetan Plateau.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: Jul 16, 2025

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

2.3K

Nomogram to predict feeding intolerance in critically ill children.

Ying Lin1, Xiaomin Wang2, Lingyan Li3

  • 1Department of Nutrition, Tianjin Children's Hospital /Tianjin University Children's Hospital, 225 Longyan Rd, Beichen Dist, Tianjin, China. yinglin@alu.scu.edu.cn.

European Journal of Pediatrics
|September 18, 2023
PubMed
Summary

Feed intolerance in critically ill children is predicted by higher PIM3 scores, mechanical ventilation, sepsis, and hypokalemia, with higher albumin levels being protective. This helps identify children at risk for better outcomes.

Keywords:
ChildrenCritically illEnteral nutritionFeed intoleranceNomogramPredictors

More Related Videos

Sucrose Preference and Novelty-Induced Hypophagia Tests in Rats using an Automated Food Intake Monitoring System
07:33

Sucrose Preference and Novelty-Induced Hypophagia Tests in Rats using an Automated Food Intake Monitoring System

Published on: May 8, 2020

10.5K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.7K

Related Experiment Videos

Last Updated: Jul 16, 2025

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
09:36

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers

Published on: July 28, 2022

2.3K
Sucrose Preference and Novelty-Induced Hypophagia Tests in Rats using an Automated Food Intake Monitoring System
07:33

Sucrose Preference and Novelty-Induced Hypophagia Tests in Rats using an Automated Food Intake Monitoring System

Published on: May 8, 2020

10.5K
A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition
00:04

A Clinical Trial Assessing the Safety, Efficacy, and Delivery of Olive-Oil-Based Three-Chamber Bags for Parenteral Nutrition

Published on: September 20, 2019

10.7K

Area of Science:

  • Pediatric critical care medicine
  • Gastroenterology
  • Clinical prediction modeling

Background:

  • Feed intolerance (FI) is linked to poor prognosis in critically ill patients.
  • Gastrointestinal dysfunction is a key component and initiator of Multiple Organ Dysfunction Syndrome (MODS).
  • Previous research indicates a significant association between FI and adverse outcomes in critically ill populations.

Purpose of the Study:

  • To characterize feed intolerance (FI) in critically ill children.
  • To identify predictors of FI in this vulnerable patient group.
  • To develop and validate a predictive model for FI in pediatric intensive care.

Main Methods:

  • Retrospective cohort study of 854 children in a Pediatric Intensive Care Unit (PICU) from January 2017 to June 2022.
  • Analysis of 18 potential factors including clinical scores, interventions, and laboratory values to predict FI.
  • Development of a predictive nomogram using multivariate logistic regression and validated through internal validation and decision curve analysis.

Main Results:

  • Feed intolerance (FI) developed in 215 out of 854 children (25.2%).
  • Six significant predictors were identified: Pediatric Index of Mortality 3 (PIM3) score, mechanical ventilation (MV), sepsis, hypokalemia, albumin, and arterial partial pressure of oxygen (PaO2).
  • Higher PIM3 score, MV, sepsis, hypokalemia, and lower PaO2 were independent risk factors; higher albumin was a protective factor. The nomogram demonstrated strong predictive value (C-index 0.940).

Conclusions:

  • A validated nomogram effectively predicts feed intolerance (FI) in critically ill children.
  • Key predictors include PIM3 score, MV, sepsis, hypokalemia, albumin, and PaO2.
  • The nomogram shows good clinical applicability and predictive performance, aiding in early identification and management of FI.