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Antimicrobial Bacterial Metabolites: Properties, Applications and Loading in Liposomes for Site-specific Delivery

Camilla A S Valença1, Ana A T Barbosa2, Silvio S Dolabella3

  • 1Post-Graduation Program in Industrial Biotechnology, University of Tiradentes, Aracaju, Sergipe, Brazil.

Current Pharmaceutical Design
|September 19, 2023
PubMed

Insights

Antibiotic resistance is a global health crisis. This review explores bacterial metabolites and liposome delivery systems to combat microbial infections and overcome drug resistance.

Area of Science:

  • Microbiology
  • Pharmacology
  • Drug Delivery Systems

Background:

  • Rising antibiotic resistance poses a significant threat to global health, diminishing treatment efficacy for infectious diseases.
  • The diminishing effectiveness of current antibiotics necessitates the discovery of novel antimicrobial agents and advanced delivery strategies.
  • Bacterial secondary metabolites offer a rich source of diverse antimicrobial compounds, yet few progress to clinical application.

Purpose of the Study:

  • To review bacterial secondary metabolites with antimicrobial potential for human and veterinary medicine.
  • To evaluate the utility of liposomes as drug delivery systems for these metabolites.
  • To explore the synergistic potential of liposomes and metabolites in overcoming antibiotic resistance.

Main Methods:

  • Literature review of scientific articles on bacterial secondary metabolites and liposome drug delivery.
  • Analysis of studies reporting antimicrobial properties of bacterial-derived compounds.
  • Assessment of research on liposomal formulations for targeted drug delivery.

Main Results:

  • Numerous bacterial secondary metabolites exhibit potent antimicrobial activities.
  • Liposomes demonstrate potential for site-specific delivery, enhancing drug efficacy.
  • Combined use of metabolites and liposomes may offer synergistic effects against resistant microbes.

Conclusions:

  • Bacterial secondary metabolites represent a promising avenue for new antimicrobial therapies.
  • Liposome-based delivery systems can improve the therapeutic index of these agents.
  • Targeted delivery of bacterial metabolites via liposomes could be a key strategy to combat antibiotic resistance.
Keywords:
Bacillus speciesLiposomesantibiotic resistanceantimicrobialsbacterial bioactivesbacterial metabolites

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