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Related Experiment Video

Updated: Jul 16, 2025

Tracking Mouse Bone Marrow Monocytes In Vivo

Tracking Mouse Bone Marrow Monocytes In Vivo

Published on: February 27, 2015

Crosstalk between bone and other organs.

Wanqiong Yuan^1,2,3, Chunli Song^1,2,3

¹Department of Orthopedics, Peking University Third Hospital, Beijing, China.

Medical Review (2021)

|September 19, 2023

Summary

This summary is machine-generated.

Bone is more than a calcium store; it acts as an endocrine organ. This study explores bone

Keywords:

bone crosstalk endocrine organs osteocalcin osteokines receptor activator for nuclear factor-κ B ligand

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Area of Science:

Endocrinology
Skeletal Biology
Systemic Physiology

Background:

Traditionally, bone was viewed as a mineral reservoir for calcium and phosphorus.
Emerging research highlights bone's role as an endocrine organ.
Bone communicates with systemic organs, influencing homeostasis.

Purpose of the Study:

To provide an overview of the complex crosstalk between bone and other organs.
To identify factors mediating this inter-organ communication.
To review mechanisms underlying diseases associated with bone crosstalk.

Main Methods:

Literature review and synthesis of current research on bone as an endocrine organ.
Analysis of signaling pathways and molecular mediators involved in bone-organ communication.
Examination of disease pathogenesis linked to disrupted bone crosstalk.

Main Results:

Bone actively participates in systemic physiological and pathological processes.
Specific factors and mechanisms mediating bone's endocrine functions have been identified.
Disruptions in bone crosstalk are implicated in various systemic diseases.

Conclusions:

Bone's endocrine role is critical for maintaining whole-body homeostasis.
Understanding bone-organ crosstalk offers new insights into disease pathogenesis.
This communication network presents novel therapeutic targets for systemic diseases.