SPE of gallic acid and ascorbic acid in fruits using polymerized deep eutectic solvent-modified substrate

Area of Science:

• Analytical Chemistry
• Materials Science

Background:

• Dispersive solid-phase extraction (d-SPE) is a crucial technique for sample preparation.
• Developing novel, efficient, and reusable extraction materials is an ongoing challenge.

Purpose of the Study:

• To synthesize and characterize novel magnetic substrates using deep eutectic solvents (DES) for d-SPE.
• To evaluate the efficiency of these substrates for the extraction of gallic and ascorbic acids.

Main Methods:

• Synthesis of porous and nonporous magnetic silica nanoparticles functionalized with DES.
• Characterization of the synthesized substrates.
• Optimization of d-SPE parameters using central composite design.
• Analysis of gallic and ascorbic acids using optimized method.

Main Results:

• The synthesized substrates demonstrated effective dispersive solid-phase extraction capabilities.
• Low limits of detection were achieved: 0.136 μM for gallic acid and 0.165 μM for ascorbic acid.
• The substrates maintained good extraction performance over three reuse cycles.

Conclusions:

• Novel DES-based magnetic nanoparticles are effective for d-SPE.
• The developed method is sensitive, efficient, and suitable for analyzing real samples.
• The reusability of the substrates enhances their practical applicability.