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Updated: Jul 16, 2025

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
Published on: August 18, 2017
Remote stereocentres do not disrupt the stereochemical coupling in homochiral [M2L3] helicates and [M4L6] tetrahedra
Rashid G Siddique1, Jacob J Whittaker1, Hydar A Al-Fayaad1
1School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Qld, 4072, Australia. j.clegg@uq.edu.au.
Abstract:
Despite the use of achiral ligands, the vast majority of metallosupramolecular assemblies containing octahedral tris-bidentate metal centres show strong stereochemical communication between metal centres, generally resulting in homochiral assemblies even though they are statistically disfavoured. Here we show that when resolved stereocentres are attached to the central part of a quaterpyridine ligand, the stereochemical coupling from this centre is insufficient to disrupt the strong stereochemical communication between metal centres in both [M2L3] helicates and [M4L6] tetrahedra.
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