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Evolution of a functionally intact but antigenically distinct DENV fusion loop.

Rita M Meganck1, Deanna Zhu2, Stephanie Dong2

  • 1Department of Molecular Microbiology and Immunology, Saint Louis University, Saint Louis, United States.

Elife
|September 19, 2023
PubMed
Summary

Researchers engineered a mutated dengue virus (DENV) variant to evade antibody-dependent enhancement, a major challenge for DENV vaccines. This modified DENV may lead to safer vaccines for individuals without prior DENV exposure.

Keywords:
dengue virusevolutionfusion loopinfectious diseasemicrobiologysaturation mutagenesisserumvaccineviruses

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