Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Improved nuclear fluorescence screening technique.

G P Hemstreet, S S West, M S Cook

    Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association
    |October 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Magnetic and electronic properties unveil polaron formation in Eu[Formula: see text]In[Formula: see text]Sb[Formula: see text].

    Scientific reports·2023
    Same author

    Expression of sex steroid receptor genes and comodulation with retinoid signaling in normal human uroepithelial cells and bladder cancer cell lines.

    Urologic oncology·2011
    Same author

    Calibration of a microspectrofluorophotometer in absolute units of radiation.

    Applied optics·2010
    Same author

    Linear polarimeter with rapid modulation . . . .: comment.

    Applied optics·2010
    Same author

    Biomarker risk assessment and bladder cancer detection in a cohort exposed to benzidine.

    Journal of the National Cancer Institute·2001
    Same author

    Case study. Risperidone-Induced neuroleptic malignant syndrome in an adolescent.

    Journal of child and adolescent psychopharmacology·2001
    Same journal

    The private funding of public research. New directions in the administration of occupational and environmental health research.

    Journal of occupational medicine. : official publication of the Industrial Medical Association·1994
    Same journal

    High-cost analysis. A closer look at the case for work-site health promotion.

    Journal of occupational medicine. : official publication of the Industrial Medical Association·1994
    Same journal

    Teaching stress management skills to occupational and environmental health physicians and practitioners. A graduate-level practicum.

    Journal of occupational medicine. : official publication of the Industrial Medical Association·1994
    Same journal

    Exposure to biogenic silica fibers and respiratory health in Hawaii sugarcane workers.

    Journal of occupational medicine. : official publication of the Industrial Medical Association·1994
    Same journal

    The detection of increased amounts of the extracellular domain of the epidermal growth factor receptor in serum during carcinogenesis in asbestosis patients.

    Journal of occupational medicine. : official publication of the Industrial Medical Association·1994
    Same journal

    Hazardous waste worker education. Long-term effects.

    Journal of occupational medicine. : official publication of the Industrial Medical Association·1994
    See all related articles

    Quantitative fluorescence image analysis using nuclear intensity (NI) cytology shows higher sensitivity and specificity for bladder cancer detection than conventional Papanicolaou (Pap) cytology. This advanced method aids in earlier and more accurate diagnosis of bladder tumors.

    Area of Science:

    • Uro-oncology
    • Medical diagnostics
    • Cytopathology

    Background:

    • Bladder cancer diagnosis relies on cytology and biopsy.
    • Conventional Papanicolaou (Pap) cytology has limitations in sensitivity and specificity.
    • Early and accurate detection is crucial for effective bladder cancer treatment.

    Purpose of the Study:

    • To evaluate the sensitivity and specificity of quantitative fluorescence image analysis (nuclear intensity cytology) for bladder cancer detection.
    • To compare the performance of NI cytology with conventional Pap cytology.
    • To assess the utility of NI cytology in screening diverse patient populations.

    Main Methods:

    • Three screening studies involving quantitative fluorescence image analysis of stained epithelial cells from urine and bladder washings.

    Related Experiment Videos

  • Comparison of nuclear intensity (NI) measurements with Papanicolaou (Pap) cytology results.
  • Validation of findings against pathological biopsy diagnoses.

    • Main Results:

    • NI cytology demonstrated higher sensitivity and specificity in detecting pathologically confirmed bladder tumors compared to Pap cytology.
    • In one study, NI cytology detected 91.1% of low-grade and 100% of high-grade tumors, versus 47% and 78% for Pap cytology, respectively.
    • Comparable results were observed across multiple study sites, including screening high-risk cohorts.

    Conclusions:

    • Quantitative fluorescence image analysis (NI cytology) offers a more sensitive and specific method for bladder cancer detection than conventional Pap cytology.
    • NI cytology facilitates earlier and more accurate diagnosis of bladder tumors.
    • This method shows promise for improved bladder cancer screening protocols.