The Diversity of Cucurbituril Molecular Switches and Shuttles

Ring translocation switches and shuttles featuring a macrocycle (or a ring molecule) navigating between two or more stations continue to attract attention. While the vast majority of these systems are developed in organic solvents, the cucurbituril (CB) macrocycles are ideally suited to prepare such systems in water. Indeed, their stability and their relatively high affinity for relevant guest molecules are key attributes toward translating the progresses made in organic solvents, into water. This concept article summarizes the findings, key advances and multiple possibilities offered by CBs toward advanced molecular switches and shuttles in water.