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Related Experiment Videos

Asbestos and airflow limitation.

Z Mohsenifar, A J Jasper, T Mahrer

    Journal of Occupational Medicine. : Official Publication of the Industrial Medical Association
    |September 1, 1986
    PubMed
    Summary
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    Asbestos exposure in shipyard workers may cause small airways dysfunction, even in nonsmokers. This dysfunction, indicated by abnormal Maximum Midexpiratory Flow Rates (MMFR), could signal increased risk for lung diseases.

    Area of Science:

    • Pulmonary Medicine
    • Occupational Health

    Background:

    • Asbestos exposure is a known risk factor for various lung diseases.
    • Small airways dysfunction can be an early indicator of lung damage.

    Purpose of the Study:

    • To investigate the prevalence of small airways dysfunction in lifelong nonsmoking shipyard workers with asbestos-related abnormalities.
    • To determine if asbestos exposure contributes to small airways dysfunction.

    Main Methods:

    • Study included 45 lifelong nonsmoking shipyard workers with asbestos-related chest roentgenogram abnormalities.
    • Exclusion criteria included pre-existing lung or cardiovascular diseases.
    • Pulmonary function tests, including spirometry before and after bronchodilator, lung volumes, diffusing capacity, and arterial blood gases, were performed.

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    Main Results:

    • All patients had normal Forced Vital Capacity (FVC) and Forced Expiratory Volume in one second (FEV1).
    • Maximum Midexpiratory Flow Rates (MMFR) were abnormal (less than 75% of predicted) in 13 workers (29%).
    • This indicates small airways dysfunction in 29% of the study population.

    Conclusions:

    • A significant percentage of asbestos-exposed, nonsmoking workers show evidence of small airways dysfunction.
    • Abnormal MMFR may be linked to asbestos exposure and could predict future risk of pulmonary fibrosis or obstructive airways disease.