Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

86
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
86
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

6.1K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.1K
Mitochondria01:37

Mitochondria

13.7K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
13.7K
Glaucoma: Overview01:25

Glaucoma: Overview

618
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
618
Unrenewable Cells00:50

Unrenewable Cells

2.3K
In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prediction of ABX<sub>3</sub> Perovskite Formation Energy Using Machine Learning.

Materials (Basel, Switzerland)·2025
Same author

A study of in-shoe plantar pressure distribution while firefighters carrying self-contained breathing apparatus in walking and running.

Journal of biomechanics·2025
Same author

lnc15qD3 expression in the NAc shell regulates the reconsolidation of opioid reward memories.

Progress in neuro-psychopharmacology & biological psychiatry·2025
Same author

[Influence of the presence or absence of the second hammertoe on clinical effect of hallux valgus].

Zhongguo gu shang = China journal of orthopaedics and traumatology·2025
Same author

Polymer nanocomposites reinforced with Al<sub>2</sub>O<sub>3</sub> nanoplates for high-temperature capacitive energy storage application.

Nanoscale·2025
Same author

Biofouling behavior and control in metallic membrane treatment of algae-laden water: exploring the diverse impacts of oxidation.

Journal of colloid and interface science·2025
Same journal

Lifelong Consumption of Freeze-Dried Parabacteroides Distasonis Improves Gut Barrier Integrity and Extends Lifespan and Health Span in Drosophila Melanogaster.

Aging and disease·2026
Same journal

Chronogeroprotection: Circadian Action Bundles for Healthy Aging.

Aging and disease·2026
Same journal

Targeting Cellular Senescence as a Therapeutic Strategy to Attenuate Pulmonary Fibrosis Associated with Metabolic Syndrome.

Aging and disease·2026
Same journal

Muscle-Brain Crosstalk in Alzheimer's Disease: Exercise-Associated FNDC5/Irisin Pathways in Preclinical Models - A Systematic Review.

Aging and disease·2026
Same journal

Extracellular Space Barrier Dysfunction Disrupts Interstitial Fluid Drainage and Is Associated with Memory Heterogeneity in Cognitive Aging.

Aging and disease·2026
Same journal

Rapamycin Attenuates Age-Related Changes in Marmoset Submandibular Gland: A Non-Human Primate Model of Human Oral Aging.

Aging and disease·2026
See all related articles

Related Experiment Video

Updated: Jul 16, 2025

SA-&#946;-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

24.0K

Aging, Cellular Senescence, and Glaucoma.

Yumeng Zhang1, Shouyue Huang1, Bing Xie1

  • 1Department of Ophthalmology, Ruijin Hospital Affiliated Medical School, Shanghai Jiaotong University, Shanghai 200025, China.

Aging and Disease
|September 19, 2023
PubMed
Summary
This summary is machine-generated.

Cellular senescence, a hallmark of aging, contributes to glaucoma by damaging cells like trabecular meshwork and retinal ganglion cells. Targeting these senescent cells shows promise for treating glaucoma and preserving vision.

More Related Videos

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

3.5K
Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.0K

Related Experiment Videos

Last Updated: Jul 16, 2025

SA-&#946;-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

24.0K
Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry
08:52

Measurement of Protein Turnover Rates in Senescent and Non-Dividing Cultured Cells with Metabolic Labeling and Mass Spectrometry

Published on: April 6, 2022

3.5K
Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.0K

Area of Science:

  • Ophthalmology
  • Gerontology
  • Cell Biology

Background:

  • Aging is a primary risk factor for glaucoma, the second leading cause of legal blindness globally.
  • Cellular senescence, characterized by stable cell cycle exit due to damage, is a key aging hallmark.
  • Glaucoma pathogenesis involves cellular senescence in critical eye cells, including trabecular meshwork and retinal ganglion cells.

Purpose of the Study:

  • To explore the biological links between aging and glaucoma, focusing on cellular senescence.
  • To summarize current data on cellular senescence in glaucoma-associated cells.
  • To discuss therapeutic strategies targeting cellular senescence for glaucoma management.

Main Methods:

  • Review of existing literature on aging, cellular senescence, and glaucoma.
  • Analysis of mechanisms contributing to glaucomatous cellular senescence (oxidative stress, DNA damage, etc.).
  • Examination of senescent cell accumulation in trabecular meshwork, retinal ganglion cells, and vascular endothelial cells.

Main Results:

  • Cellular senescence, driven by factors like oxidative stress and mitochondrial dysfunction, plays a significant role in glaucoma.
  • Accumulation of senescent cells in key ocular tissues contributes to glaucoma pathology.
  • Therapies eliminating senescent cells have shown potential in improving vision and reducing retinal ganglion cell death in glaucoma models.

Conclusions:

  • Cellular senescence is a critical factor in the aging-related development and progression of glaucoma.
  • Targeting senescent cells offers a promising therapeutic avenue for managing glaucoma.
  • Further research into senolytics could lead to novel treatments for vision preservation in glaucoma patients.