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A dual-role for IL-10: From leukemogenesis to the tumor progression in acute lymphoblastic leukemia

Flavio Souza Silva1, Amanda Barros-Lima1, Mateus Souza-Barros1

  • 1Programa de Pós-Graduação em Imunologia Básica e Aplicada, Instituto de Ciências Biológicas, Universidade Federal do Amazonas (UFAM), Manaus, Brazil; Diretoria de Ensino e Pesquisa, Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas (HEMOAM), Manaus, Brazil.

Cytokine
|September 19, 2023
PubMed

Insights

Interleukin-10 (IL-10) plays a dual role in childhood acute lymphoblastic leukemia (ALL), influencing its development and progression. This review explores IL-10

Area of Science:

  • Immunology
  • Pediatric Oncology
  • Molecular Biology

Background:

  • Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer.
  • Children with ALL often have a deregulated immune response and environmental exposures contributing to disease onset.
  • Interleukin-10 (IL-10) is a key cytokine in immune response regulation.

Purpose of the Study:

  • To explore the dual role of IL-10 in the development and progression of ALL.
  • To describe the biological characteristics, immunological mechanisms, genetics, and clinical implications of IL-10 in ALL.

Main Methods:

  • This is a review article, synthesizing existing literature on IL-10 and ALL.
  • Analysis of biological characteristics, immunological mechanisms, and genetics of IL-10.
  • Evaluation of IL-10's impact on the leukemia microenvironment and clinical implications.

Main Results:

  • IL-10 acts as a paradoxical mediator in ALL.
  • IL-10 influences ALL development by regulating inflammatory processes.
  • Increased IL-10 in the leukemia microenvironment promotes malignancy progression.

Conclusions:

  • IL-10 plays a critical and complex role throughout the natural history of ALL.
  • Understanding IL-10's dual function is crucial for its clinical implications in pediatric ALL.

Keywords:
Antitumor immunityChildhood leukemiaImmune-suppressive cytokineLeukemogenesisTumor microenvironment

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