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An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
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Postmenopausal bleeding after COVID-19 vaccination.

Tia L Kauffman1, Stephanie A Irving1, Neon Brooks1

  • 1Kaiser Permanente Center for Health Research, Portland, OR.

American Journal of Obstetrics and Gynecology
|September 19, 2023
PubMed
Summary
This summary is machine-generated.

COVID-19 vaccination did not increase postmenopausal bleeding diagnoses. New-onset bleeding after vaccination was rare, with most cases attributed to other causes like uterine lesions or hormone therapy.

Keywords:
COVID-19 vaccinationincidence ratespostmenopausal bleedingsegmented regressiontemporal scan statisticuterine bleedingvaccine adverse events

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Area of Science:

  • Gynecology
  • Immunology
  • Public Health

Background:

  • Limited data exists on postmenopausal bleeding following COVID-19 vaccination.
  • Research on menstrual changes post-vaccination primarily focuses on premenopausal individuals.

Purpose of the Study:

  • To analyze trends in postmenopausal bleeding diagnoses before and after COVID-19 vaccine introduction.
  • To characterize new-onset postmenopausal bleeding cases occurring after COVID-19 vaccination.

Main Methods:

  • Segmented regression analysis of incident postmenopausal bleeding diagnoses (≥45 years) from 2018-2021.
  • Chart review of postmenopausal bleeding cases within 60 days of COVID-19 vaccination.
  • Exclusion of individuals with pre-existing bleeding conditions or other risk factors.

Main Results:

  • No significant difference in postmenopausal bleeding incidence before and after vaccine introduction (P=.59).
  • 104 cases diagnosed within 60 days of vaccination; 76% confirmed as postvaccination bleeding.
  • Common causes included uterine/cervical lesions (50%), hormone therapy (13%), and proliferative endometrium (13%).

Conclusions:

  • COVID-19 vaccine introduction was not associated with increased postmenopausal bleeding diagnoses.
  • Postmenopausal bleeding following COVID-19 vaccination is a rare occurrence.