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Related Experiment Video

Updated: Jul 16, 2025

Improved Generation of Induced Cardiomyocytes Using a Polycistronic Construct Expressing Optimal Ratio of Gata4, Mef2c and Tbx5
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Gene of the month: GATA3.

Zekai Qiang1, Ibrahim Jubber1, Kirsty Lloyd2

  • 1Academic Urology Unit, The University of Sheffield, Sheffield, UK.

Journal of Clinical Pathology
|September 19, 2023
PubMed
Summary

GATA binding protein 3 (GATA3) is a transcription factor crucial for cell differentiation and gene regulation. Its role in cancer, particularly bladder cancer, and use as an immunohistochemical marker are reviewed.

Keywords:
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Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor regulating gene expression by binding DNA and remodeling chromatin.
  • Post-translational modifications influence GATA3 activity, which is vital for cellular differentiation during development.

Approach:

  • This review synthesizes current knowledge on GATA3 structure and function.
  • It examines GATA3's established roles in various cancers, including breast and bladder cancer.
  • The paper also evaluates GATA3's utility and limitations as an immunohistochemical marker.

Key Points:

  • GATA3 mutations are implicated in breast and bladder cancers.
  • GATA3 expression defines the luminal subtype of bladder cancer, impacting immune status and treatment outcomes.
  • Clinical relevance extends to squamous cell carcinomas and soft tissue sarcomas.

Conclusions:

  • GATA3 is a key regulator of cellular processes with significant implications in oncology.
  • Understanding GATA3's function and its immunohistochemical properties is crucial for cancer diagnosis and treatment.