Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

295
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
295
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

246
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
246
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.4K
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists01:28

Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists

378
Prokinetic agents are specialized medications that stimulate gastrointestinal (GI) motility, promoting food movement through the GI tract. Dopamine, an inhibitory neurotransmitter, plays a significant role in this process, reducing GI motility and indirectly controlling the speed of digestion. Dopamine receptor antagonists, such as metoclopramide and domperidone, offer a unique advantage as prokinetic agents. By blocking the dopamine receptors, these drugs increase GI motility, improving food...
378
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

592
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
592
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

196
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
196

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Updated Algorithm for the Management of Restless Legs Syndrome.

Mayo Clinic proceedings·2026
Same author

Shared local brain dynamics in pediatric and adult non-rapid eye movement parasomnias.

Sleep·2026
Same author

Aerobic exercise as a non-pharmacological approach to restless legs syndrome: Evidence from an ID-induced model.

Life sciences·2026
Same author

Ru-SATED scale and Sleep Health Index: A systematic review of two leading multidimensional sleep health measures and frameworks across the globe.

Sleep medicine reviews·2026
Same author

Burden among participants with central disorders of hypersomnolence in six European countries.

Sleep medicine·2026
Same author

Dynamics of slow wave sleep in advanced Parkinson's disease: An entropy-based study.

Neurobiology of disease·2026

Related Experiment Video

Updated: Jul 16, 2025

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
05:51

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

3.8K

Slow wave activity across sleep-night could predict levodopa-induced dyskinesia.

Ninfa Amato1, Serena Caverzasio1,2, Mauro Manconi1,2,3

  • 1Parkinson Disease and Movement Disorder Center, Neurocenter of Southern Switzerland, EOC, Via Tesserete 46, 6903, Lugano, Switzerland.

Scientific Reports
|September 19, 2023
PubMed
Summary

Parkinson's disease patients with levodopa-induced dyskinesia show disrupted slow wave activity (SWA) during sleep. A decrease in overnight SWA predicted the onset of dyskinesia, suggesting a link between sleep and Parkinson's symptoms.

More Related Videos

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

2.8K
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.2K

Related Experiment Videos

Last Updated: Jul 16, 2025

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
05:51

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

3.8K
Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

2.8K
Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

15.2K

Area of Science:

  • Neuroscience
  • Sleep Medicine
  • Movement Disorders

Background:

  • Parkinson's disease (PD) is associated with disruptions in synaptic plasticity.
  • Levodopa-induced dyskinesia (LID) is a common motor complication in PD patients treated with levodopa.
  • Slow wave activity (SWA) during sleep is implicated in synaptic downscaling, a process crucial for memory consolidation and neuronal homeostasis.

Purpose of the Study:

  • To investigate the relationship between SWA and the development of LID in PD patients.
  • To determine if SWA changes can predict the emergence of LID.
  • To explore the role of SWA-mediated synaptic downscaling in LID pathogenesis.

Main Methods:

  • Polysomnography was conducted on 15 PD patients with LID prior to the onset of dyskinesia.
  • Slow wave sleep (SWS) epochs were analyzed for SWA power, segmented into early and late sleep stages.
  • Linear regression modeling was employed to assess the predictive value of SWA on LID emergence.

Main Results:

  • A significant decrease in overnight SWA was observed in PD patients who developed LID.
  • Linear regression analysis demonstrated that the overnight SWA decrease could predict the time to LID emergence.
  • These findings support a correlation between reduced SWA and the development of levodopa-induced dyskinesia.

Conclusions:

  • The study provides evidence linking SWA-mediated synaptic downscaling disruptions to LID development in Parkinson's disease.
  • Reduced SWA may serve as a potential biomarker for predicting LID onset.
  • Further research into sleep-targeted therapies could offer novel strategies for preventing or mitigating LID in PD patients.