Electrochemical sensor using cobalt oxide-modified porous carbon for uric acid determination.

Area of Science:

• Electrochemistry
• Materials Science
• Biomedical Sensing

Background:

• Uric acid detection is crucial for diagnosing conditions like gout and kidney disease.
• Developing sensitive and selective electrochemical sensors is essential for accurate uric acid monitoring.

Purpose of the Study:

• To create a novel electrochemical sensor for enhanced uric acid detection.
• To utilize a cobalt oxide-modified porous carbon@multi-walled carbon nanotube composite for electrode modification.

Main Methods:

• Synthesized ZIF-67 on carbon nanotubes using CTAB as a template.
• Obtained cobalt oxide-modified porous carbon@MWCNT composite via high-temperature carbonization.
• Fabricated an electrochemical sensor by modifying the electrode with the composite material.

Main Results:

• The composite material exhibited Co-N and Co-O active sites, enhancing uric acid oxidation.
• Achieved a linear detection range of 1 to 40 μM for uric acid.
• Demonstrated a low detection limit of 0.09 μM for uric acid.
• Successfully applied the sensor for uric acid determination in human serum samples.

Conclusions:

• The developed electrochemical sensor offers high sensitivity and selectivity for uric acid detection.
• The cobalt oxide-modified porous carbon@MWCNT composite is a promising material for electrochemical sensing applications.
• The sensor's effectiveness in real serum samples highlights its potential for clinical diagnostics.