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Association between MTTP genotype (-493G/T) polymorphism and hepatic steatosis in hepatitis C: a systematic review

Xiaoxia Wang1, Yu Cao2, Jia Guo1

  • 1Department of Medical Oncology, Beijing YouAn Hospital, Capital Medical University, Beijing, China.

Lipids in Health and Disease
|September 19, 2023
PubMed
Abstract

Insights

Microsomal triglyceride transporter protein (MTTP) genotype -493G/T polymorphism is associated with hepatic steatosis in Hepatitis C virus genotype 3 patients. Dominant mutations in the T allele increase susceptibility to fatty liver disease.

Area of Science:

  • Hepatology
  • Genetics
  • Molecular Biology

Background:

  • Hepatitis C virus (HCV) infection is linked to hepatic steatosis, a condition increasing liver cancer risk.
  • Microsomal triglyceride transporter protein (MTTP) plays a role in lipid metabolism and CD1d antigen presentation.
  • Investigating the association between MTTP genotype (-493G/T) polymorphism and hepatic steatosis in HCV patients is crucial.

Approach:

  • A comprehensive literature search was conducted across multiple databases (PubMed, Cochrane, CNKI, Web of Science, Embase, CBM).
  • Study quality was assessed using the Newcastle-Ottawa Scale (NOS), and data were analyzed using Stata.
  • Heterogeneity, publication bias, and sensitivity were evaluated using established statistical methods (Cochran's Q, I², Egger's, Begg's tests, Funnel plots).

Key Points:

  • A significant positive association was found between hepatic steatosis and HCV genotype 3 under a dominant model of the MTTP genotype (-493G/T) (OR = 11.57, P < 0.001).
  • No significant correlation was observed for recessive, homozygous, or heterozygous models.
  • Sensitivity analysis confirmed the stability of the findings, with no significant publication biases detected.

Conclusions:

  • Dominant mutations in the T allele of the MTTP genotype (-493G/T) are associated with increased susceptibility to hepatic steatosis.
  • This association is particularly evident in patients with Hepatitis C virus genotype 3.
  • The findings highlight a potential genetic marker for fatty liver disease in specific HCV populations.
Keywords:
Genotype polymorphismHepatic steatosisHepatitis CMTTP

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