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Related Experiment Video

Updated: Jul 16, 2025

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Wireless agents for brain recording and stimulation modalities.

Ilhan Bok1,2,3, Adam Vareberg1,3, Yash Gokhale1,3

  • 1Department of Biomedical Engineering, University of WI - Madison, 1550 Engineering Dr, Madison, WI, Rm 2112, USA.

Bioelectronic Medicine
|September 19, 2023
PubMed
Summary
This summary is machine-generated.

New wireless brain sensors and modulators offer advanced in situ recording and stimulation, moving beyond invasive wired probes. These miniaturized technologies promise enhanced neurological diagnostics and therapeutics.

Keywords:
ElectromagneticImplantableInjectableMagnetic resonance imaging (MRI)MagnetoelectricMicroscaleNanoparticlesNanoscaleNeuroimagingRadio frequency (RF)Ultrasound imaging

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Materials Science

Background:

  • Traditional brain probes are bulky and invasive.
  • Advancements in miniaturization and materials are enabling new wireless technologies.
  • Current limitations necessitate novel approaches for in situ brain monitoring and intervention.

Purpose of the Study:

  • To survey state-of-the-art wireless agents for brain recording and stimulation.
  • To evaluate emerging technologies based on size, delivery, specificity, and resolution.
  • To assess the potential of these agents in diagnostics and therapeutics.

Main Methods:

  • Review of implantable and injectable micro/nano-scale electronic devices.
  • Analysis of nanoparticles and molecular conjugates for functional imaging (MRI, US).
  • Assessment of minimally invasive stimulation methods (magnetic, electrical, thermal, optogenetic).

Main Results:

  • Wireless sensors and modulators are emerging with improved capabilities.
  • Technologies range from simple near-field RF devices to sophisticated imaging agents.
  • Minimally invasive stimulation techniques are being developed alongside recording devices.

Conclusions:

  • Wireless brain technologies are transforming neurological diagnostics and therapeutics.
  • These advancements offer alternatives to traditional invasive probes.
  • The integration of compatible imaging systems is crucial for realizing the full potential.