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Related Experiment Videos

Omphalocele: a 25-year experience.

S Yazbeck, M Ndoye, A H Khan

    Journal of Pediatric Surgery
    |September 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    This 25-year study of 92 neonates with omphalocele found that associated anomalies significantly impact survival. Improved outcomes, especially for complex cases, are linked to advancements like total parenteral nutrition (TPN).

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    Area of Science:

    • Pediatric Surgery
    • Neonatal Care
    • Congenital Anomalies

    Background:

    • Omphalocele is a congenital abdominal wall defect affecting neonates.
    • Historically, omphalocele management faced high mortality rates, particularly with associated anomalies.
    • Understanding prognostic factors is crucial for improving neonatal outcomes.

    Purpose of the Study:

    • To retrospectively analyze outcomes for neonates with omphalocele over a 25-year period.
    • To identify factors influencing mortality and survival rates in omphalocele cases.
    • To evaluate the impact of medical advancements on omphalocele management.

    Main Methods:

    • Retrospective review of 92 neonates diagnosed with omphalocele between 1958 and 1983.
    • Data collection included birth weight, associated anomalies, treatment modalities, and outcomes.

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  • Analysis of mortality rates before and after 1974, correlating with the introduction of total parenteral nutrition (TPN).

    • Main Results:

    • Overall mortality rate was 37%, with associated congenital anomalies being the primary cause of death.
    • Mortality decreased from 50% before 1974 to 31.5% after 1974, coinciding with the advent of TPN.
    • Survival rates improved significantly, with more neonates, including those with major anomalies, surviving post-1973.

    Conclusions:

    • Associated congenital anomalies are the main determinant of mortality in omphalocele.
    • Total parenteral nutrition (TPN) and improved mechanical ventilation significantly decreased mortality.
    • Modern management allows for the survival of a greater number of neonates with complex omphalocele and associated malformations.